The Red Devils will feel confident in claiming all three points, as Newcastle have won just one of their last 35 trips to Old Trafford.
Ole Gunnar Solskjaer’s outfit will need to win today – and embark on a long winning run of their own – if they are to challenge Manchester City for the league title.
Here’s everything you need to know about the match:
The fixture will kick-off at 7pm GMT at Old Trafford.
The match is live on BT Sport 1, with coverage starting from 6.30pm GMT. Subscribers can also stream the game live on the BT Sport website and app.
Edinson Cavani, Donny van de Beek and Scott McTominay will be assessed after the two summer signings missed out on their Europa League win over Real Sociedad this week, although McTominay played. Paul Pogba and Phil Jones are out for Man United.
Callum Wilson is out with a hamstring injury for Newcastle, joining Fabian Schar, Federico Fernandez and Javi Manquillo as absentees. Jeff Hendrick is back from suspension.
Man United: De Gea, Wan-Bissaka, Lindelof, Maguire, Shaw, Matic, Fred, Greenwood, Fernandes, Rashford, Cavani
Newcastle: Darlow, Murphy, Lascelles, Clark, Lewis, Hayden, Shelvey, Willock, Almiron, Saint-Maximin, Gayle
Man United have been inconsistent in the Premier League recently, but they reminded everyone of their quality in their dominant Europa League win this week. Newcastle might not be able to stop Fernandes and co. Man United3-1 Newcastle.