European giants United and Milan both have a rich history of success and memorable ties in European competitions and will be hoping for more of the same this week.
United won the Manchester derby on Sunday and are still in the top-four running in the Premier League, but Ole Gunnar Solskjaer will need a trophy to vindicate the good work he has done in turning things round at Old Trafford.
The game kicks off at 5.55pm.
Where can I watch it?
The match will be televised live on BT Sport. BT Sport subscribers will be able to watch the match online via the website or BT app.
First-choice goalkeeper David de Gea is thought to still be in Spain following the birth of his child, which would give Dean Henderson a chance to start. Henderson played in both legs against Real Sociedad and also in Premier League ties with Crystal Palace and City, keeping clean sheets on all occasions.
Milan also have some injuries, with Ibrahimovic and Ismael Bennacer still out, and Hakan Calhanoglu, Ante Rebic and Theo Hernandez all doubts and unlikely to play at Old Trafford. Milan boss Stefano Pioli has recently given rests to the central-defensive duo Simon Kjaer and Alessandro Romagnoli, with Chelsea loanee Fikayo Tomori an option to replace either if needed.
Man United: Henderson, Wan-Bissaka, Lindelof, Maguire, Shaw, Fred, McTominay, Greenwood, Fernandes, James, Cavani
AC Milan: Donnarumma, Calabria, Kjaer, Romagnoli, Dalot, Tonali, Kessie, Saelemaekers, Diaz, Castillejo, Leao
With United full of confidence off the back of their Manchester derby victory, they will fancy their chances. However, the side’s inconsistency may catch them out against Milan, who hope to take something away from Old Trafford. Man United 1-0 AC Milan.