Ole Gunnar Solksjaer’s men bounced back well, initially falling a goal down before recovering to defeat Fulham on Wednesday as Paul Pogba stole the show once again.
United will also find comfort in the fact that they are playing at home in this cup tie.
Since a 1-1 draw with West Ham in the quarter-final back in 2015-16, the Red Devils have won their last seven FA Cup ties at home without conceding a single goal.
This does not bode well for the visitors, who have been struggling to find the net since the turn of the year.
Liverpool are yet to score in the league in 2021, with their only goals coming in a 4-1 win over a youthful Aston Villa side in the previous round of the FA Cup.
Here’s everything you need to know about the match:
The fixture will kick-off at 5pm GMT at Old Trafford.
The match is live on BBC One and BBC One HD, with coverage starting from 4:30pm GMT.
Dean Henderson and Alex Telles could be handed starts for United, but Ole Gunnar Solskjaer will still field a strong team – so Bruno Fernandes, Harry Maguire and Edinson Cavani are all in line to play once more.
Mohamed Salah and Roberto Firmino are set to return to the starting line-up while Sadio Mane will be rested, but Jordan Henderson could miss out with a muscle injury. Diogo Jota and Naby Keita are out.
Manchester United: Henderson, Wan-Bissaka, Lindelof, Maguire, Telles, McTominay, Matic, Rashford, Fernandes, Pogba, Cavani
Liverpool: Alisson, Williams, Phillips, Fabinho, Tsimikas, Milner, Thiago, Jones, Salah, Firmino, Minamino
Liverpool are criminally out of form, particularly after the home loss to Burnley, while Manchester United continue to grind out favourable results. Both sides will go for the win in a game that could define their seasons, for better and worse, but I think the home side will prevail. Manchester United 1-0 Liverpool.