City are also aiming to make amends after November’s return fixture, when Spurs put on a clinic in counter-attacking football, soaking up City’s pressure before hitting them on the break as Son Heung-min and Giovani Lo Celso condemned City to a 2-0 defeat.
Since then both club’s fortunes have changed dramatically, with Spurs falling away and City surging to the top of the table.
Pep Guardiola’s side can claim a record-breaking 16th victory in succession at the Etihad Stadium, and Jose Mourinho will be desperate to scupper that plan.
Here is everything you need to know.
Man City vs Tottenham is today, Saturday 13 February, and kick-off is at 5.30pm GMT.
The match will broadcast live on Sky Sports in the UK. Customers can stream online via the Sky Sports website and the Sky Sports app.
Pep Guardiola is hopeful Ruben Dias will recover from illness to play after training on Friday, and Rodri has also been passed fit. Fernandinho and Nathan Are remain injured.
Harry Kane is expected to start. Gareth Bale faces a late fitness test and Serge Aurier could return. Sergio Reguilon remains out.
Manchester City: Ederson, Cancelo, Dias, Stones, Zinchenko, Rodri, Gundogan, Bernardo Silva, Sterling, Jesus, Foden
Tottenham: Lloris, Aurier, Dier, Sanchez, Davies, Hojbjerg, Sissoko, Son, Ndombele, Bergwijn, Kane
City will surely have too much quality for Spurs. Man City 2-0 Tottenham.