The game is taking place in Budapest, Hungary due to Germany’s coronavirus travel restrictions.
Gladbach have never got to this stage of the competition before and will be up against it when they take on the runaway Premier League leaders.
The German club are currently eighth in the Bundesliga, outside the European places.
Here is everything you need to know.
Gladbach vs Man City kicks off tonight at 8pm GMT.
The game will be broadcast live on BT Sport in the UK. Subscribers can stream online via the BT Sport website and the BT Sport app.
Pep Guardiola says every City player is now fit except for defender Nathan Ake. Marco Rose reports no injuries in his senior Gladbach squad.
Gladbach: Lainer, Ginter, Elvedi, Bensebaini; Kramer, Neuhaus; Wolf, Stindl, Hofmann; Plea
Manchester City: Ederson; Walker, Dias, Stones, Cancelo; Rodri; Sterling, De Bruyne, Gundogan, Foden; Jesus
This Gladbach side are not in great form and manager Marco Rose’s announcement that he will depart for Dortmund in the summer cannot have helped matters. City are flying and should be far too good. Gladbach 0-3 City.