The Gunners impressed against Leeds before misfiring in their Europa League first leg against Benfica, with aBukayo Saka goal earning a 1-1 draw.
Manchester City have been in imperious form, winning 16 consecutive matches in all competitions.
They have a European first leg of their own to look forward to on Wednesday, when they will take on BorussiaMochengladbach in the Champions League.
Here’s everything you need to know about the match:
The match is live onSky Sports Premier League and Main Event, with coverage starting from 4:15pm GMT.
Arsenal will be without Thomas Partey, who is recovering from a hamstring injury, but Kieran Tierney could start.
Pep Guardiola confirmed that every member of his squad – with the exception of Nathan Ake – is fit, although Ilkay Gundogan will be assessed. Sergio Aguero and Kevin de Bruyne could both make appearances.
Arsenal: Leno,Bellerin, Luiz, Gabriel, Tierney, Ceballos, Xhaka, Saka, Odegaard, Pepe, Aubameyang
Manchester City: Ederson, Cancelo, Stones, Dias, Zinchenko, Rodri, De Bruyne, Sterling, Silva, Foden, Jesus
Arsenal have found form in recent weeks and looked good against Leeds, but City are in incredible form and the Gunners will have one eye on their important second leg in the Europa League. 2-0 Manchester City.